Two sample MR report
PARK7_Monocyte (Mono) against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 6 | 0.3815713 | 0.9395299 | 0.7054353 |
| Weighted median | 6 | -0.0463188 | 0.0196402 | 0.0183554 |
| Inverse variance weighted | 6 | -0.0507638 | 0.0162068 | 0.0017347 |
| Simple mode | 6 | -0.0405938 | 0.0311777 | 0.2496631 |
| Weighted mode | 6 | -0.0402701 | 0.0261597 | 0.1843297 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.3765822 | 4 | 0.9843489 |
| Inverse variance weighted | 0.5883935 | 5 | 0.9885285 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.1327757 | 0.2884988 | 0.6692579 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 5.27e-05 | 0 | TRUE | 0.4921399 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
